Keeping the plan on track Once a weekly cadence is set, sticking with it supports the consistency that adherence-sensitive effects depend on
This approach minimizes the intensity of initial side effects like water retention and flushing
(accessed 10 July 2024)
Research suggests that L-carnitine may have a positive effect on testosterone production
For patients at high risk of cardiovascular events particularly those with established atherosclerotic disease current guidelines from the ADA and ESC now favour GLP-1 receptor agonists as a preferred second-line therapy after metformin

Potential benefits of using GLP-1 receptor agonists after gastric sleeve surgery include: Enhanced weight loss : Observational studies suggest post-bariatric patients using GLP-1 receptor agonists may achieve additional weight reduction, typically around 510% of body weight, though individual responses vary considerably Improved glycaemic control : Particularly beneficial for patients with type 2 diabetes or prediabetes, as GLP-1 agonists enhance insulin secretion and reduce blood glucose levels Reduced appetite : These medications can help patients who struggle with persistent hunger despite surgical intervention Cardiovascular benefits : Semaglutide has demonstrated cardiovascular risk reduction in people with established cardiovascular disease, which may benefit eligible post-bariatric patients with this specific risk profile Maintenance of weight loss : May help prevent weight regain during the critical maintenance phase Potential risks and considerations include: Gastrointestinal side effects : Nausea, vomiting, diarrhoea, and constipation are common, particularly during dose escalation
