Cancer 64 KuniiE.OguriT.KasaiD.OzasaH.UemuraT.TakakuwaO.et al (2015)
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We review cellular therapies and repurposed drugs, such as nilotinib, inosine, isradipine, iron chelators and anti-inflammatories, and discuss how their success in preclinical models has paved the way for clinical trials
Mechanistically, total intracellular iron alone is not the whole storyhow a tumor uses iron (for DNA repair, energy metabolism, redox buffering, etc.) and the cells lineage-specific biology determine whether ferritin acts mainly as a protective iron reservoir or as a regulator of metabolism and redox state [3, 88]
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