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Semaglutide and tirzepatide also enhance secretion of water and electrolytes into the intestinal lumen through GLP-1 receptors in the colon, a mechanism that supports appetite suppression but occasionally produces loose stool consistency
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has received speaking fees from AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Eli Lilly, Merck, Novo Nordisk, Sanofi and Novartis and research grants from Bristol Myers Squibb
More than simple antioxidant scavengers
The FDA's draft guidance on obesity drug trials recommends monitoring for this in women [8]
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