References: Mercury and protein thiols: Stimulation of mitochondrial F1FO-ATPase and inhibition of respiration Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA Mercury has an affinity for the brain References: The Toxicology of Mercury and Its Chemical Compounds (Clarkson, Thomas, Magos, Laszlo, 2006) (a rather complete introduction to mercury toxicity) "The concentration in brain is about 5 times than in scalp hair about 250 times the corresponding concentration in blood" "Animal data including primates indicate that brain levels in the newborn may be as high as five times the corresponding levels in the mother" "Experimental work on rats has shown that methylmercury gains entry into the endothelial cells of the bloodbrain barrier as a complex with cysteine (Kerper et al., 1992
doi:10.1111/dom.15305
From a therapeutic perspective, future efforts should focus on identifying and validating novel ferroptosis regulators, particularly those targeting non-canonical pathways
This could be the mechanism by which XO inhibitors provide protective effects in ischemia/reperfusion-related conditions (Khatib et al., 2001)
I., Redondo-Flrez, L., Martn-Rodrguez, A
Arthritis Rheumatism 43 , 15601570 (2000)