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12,13 Modifications to prolong the half-life of GLP-1 RAs include sequence substitutions conferring resistance to DPP-4, along with acylation (liraglutide and semaglutide), covalent bonding to modified Ig fragment crystallisable domain (dulaglutide), or covalent bonding to albumin
(Flatter Me says that GLP-1 doubled, but the study authors dont give a level
95% CI 0.61 0.98
Additional generics for Saxenda may enter the market on or after Feb
Enticing more employers to cover GLP-1s would obviously benefit Express Scripts
13 The first four trials were designed primarily to assess cardiovascular safety in patients with T2D and yielded unexpected beneficial results
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