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The study identifies butyrate supplementation as a readily translatable strategy to counteract gut-derived, BMP-induced neurodegeneration
Kisspeptin-10 The Master Switch of the HPG Axis What it does: Kisspeptin-10 stimulates the hypothalamus to release gonadotropin-releasing hormone (GnRH), which triggers luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
Pastural et al., 2009)
FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012
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