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Its mechanisms include: Actin polymerization mobilizes cellular building blocks for tissue repair Cell migration accelerates fibroblast and keratinocyte movement to injury sites Angiogenesis promotes new blood vessel formation via VEGF upregulation Anti-inflammatory reduces IL-1 and TNF- at injury sites TB-500's smaller molecular size gives it excellent tissue distribution throughout the body

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10.1001/jama.2023.18588 345 NihartA

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PAI-1, plasminogen activator inhibitor type 1

During ONeills tenure, these amendments were eventually found to be unconstitutional, but they helped ONeill prior to that ruling