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Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases, with patients bearing a high symptomatic burden and physical limitations that impact their daily lives

This also signals an important shift for women in midlife, especially those navigating menopause

Common reports include: Waking fewer times during the night Feeling more refreshed upon waking Improved daytime energy and mood Reduced stress reactivity Better recovery from exercise The stress-modulating effects often become noticeable during this window as cortisol patterns normalize

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While alpha-MSH is more potent, KPV's lack of side effects and ease of administration make it a subject of research interest