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Eur J Drug Metab Pharmacokinet 41:839844

Regarding FDA approval: because this is a compounded product, it is not directly FDA-approved

Why bedtime works so well: Maximizes growth hormone release during natural peak hours Enhances sleep quality and duration Supports overnight recovery and tissue repair Minimizes interference from food and daily activities A 2018 study found that 100-300 g of Ipamorelin taken before bedtime significantly improved sleep efficiency and slow-wave sleep duration in middle-aged adults [5]

This helps maintain firmness and reduces the look of fine-lines/wrinkles

PMCID: PMC9412377 Fatemeh G, Sajjad M, Niloufar R, Neda S, Leila S, Khadijeh M (2022) Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials