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This combined approach results in improved glycemic control and substantial weight reduction, with clinical trials demonstrating HbA1c reductions of 1.9% to 2.4% and weight loss of approximately 15% to 22% of body weight at the highest doses in specific trials such as SURMOUNT-1

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Participants were randomly assigned 1:1:1:1 to retatrutide 4 mg, 9 mg, or 12 mg, or placebo, with all retatrutide arms initiating at 2 mg and escalating every 4 weeks to the target dose