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29 Taken together, accumulating evidence suggests that children with autism have a more oxidized extracellular (plasma) and intracellular immune cell microenvironment than age-matched unaffected control children

Biol Rev Camb Philos Soc

A study in The New England Journal of Medicine found that 59 percent of patients with NASH (non-alcoholic steatohepatitis) who took a high dose of semaglutide for 72 weeks saw improvement without worsening of fibrosis (or scarring)

However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])

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