Toshchakov, V
Similar to other TOPO1i payloads like DXd and SN-38, ED04 is expected to possess adequate membrane permeability to facilitate a bystander effect, which is likely contributing to the encouraging efficacy observed in HER2-heterogeneous breast cancer populations
Signs of allergic reaction Allergic reactions to peptides are uncommon but possible
Soriano, S., Curry, K., Sadrameli, S
Coffee enemas carry significant health risks including rectal perforation, severe electrolyte disturbances that can cause cardiac arrhythmias, caffeine toxicity, dehydration, thermal burns, and serious infections
doi:10.1351/pac199365061189