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Clinical trial data on weight outcomes Compared to conventional anti-obesity drugs, tirzepatide yields impressive weight reduction results
V., Metcalfe, A., Nettel-Aguirre, A., et al
Your family or other caregivers should also be alert to changes in your mood or symptoms
Rare allergic reactions, particularly in individuals with sensitivities to specific additives
Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks
Dosage and medication selection must always be determined by a prescribing physician
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