J Biol Chem 278:4686946877 Conklin PL, Foyer CH, Hancock RD, Ishikawa T, Smirnoff N (2024) Ascorbate acid metabolism and functions
Furthermore, glutathione production is highest while we sleep
System Xc(-): a key regulatory target of ferroptosis in cancer
However, we found that the DMSA had no significant effects on liver transaminases (AST and ALT), perhaps because we treated for only 3 days at a time, with 11 days in-between
Research note: Studies on hemodialysis patients show they often have lower blood glutathione levels than healthy adults suggesting glutathione depletion is a feature of kidney disease, not a cause
Given that ROS that drive ferroptosis is reduced by GSH, the effect of cystine limitation on ferroptosis is mainly ascribed to the loss of antioxidant capacity