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Henquin, J

Until such studies are conducted, the combination remains investigational and should be approached with appropriate caution, written informed consent, and consideration of FDA MedWatch reporting for any adverse events that occur with off-label combination use

I feel the same as you I have adopted the same type of reasoning with my patients as I try to explain what we know and what we dont know

Do not use if outer bottle seal is missing or damaged

D.SammariniG.ZanottiF.RossiG.et al (2020)

Junctional adhesion molecules (JAMs): cell adhesion receptors with pleiotropic functions in cell physiology and development