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Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

Only if your healthcare provider prescribes it and provides proper training

You should take a daily multivitamin that contains 200% of the daily values

If experiencing anaphylaxis, or a severe allergic reaction, it is also best to seek medical advice

doi:10.2174/1871527318666190227205359

Adequate levels support normal energy metabolism, which may help reduce fatigue related to deficiency