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Physiological function of glucagon-like peptide-1 (GLP-1)

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Mechanisms of action and therapeutic application of glucagon-like peptide-1. Cell Metabolism.

Statistical analysis All experiments were performed independently at least three times and the data were shown as mean and S.E.M

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I think most people think about these processes in terms of a single, ideal bound conformation of the peptide to the receptor as the basis for signalling, says Gellman, but Im increasingly suspecting that certain modes of dynamics are critical for signalling. He is now trying to design this structural variability into his hybridtides to see if this will improve on the performance of GLP-1 drugs