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doi: 10.3389/fphar.2014.00170 Received 01 May 2014 Accepted 30 June 2014 Published 16 July 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by George Anthony Oyler, Synaptic Research, USA

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But plausibility is not efficacy, the drugs effect size even in its approved use is modest, and it has never been tested against the specific pathophysiology of depression-related dysfunction