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Sikiric P, Jelovac N, Jelovac-Gjeldum A, Dodig G, Staresinic M, Anic T, et al

The credit applies regardless of insurance reimbursement status on the unreimbursed portion

It belongs to a novel class of agents known as triple agonists , meaning it simultaneously activates three distinct hormone receptors: GIP receptor (glucose-dependent insulinotropic polypeptide) GLP-1 receptor (glucagon-like peptide-1) Glucagon receptor This triple mechanism of action distinguishes retatrutide from currently approved agents such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 agonist)

Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, et al

3), comparisons are limited due to differences in endpoint definitions across studies: nevertheless, CVOTs results suggest substantial kidney protection with both monotherapy and combination therapy, except for the FLOW trial

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