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The trade-off is that the carrier is a large addition to the matrix: it changes the background in protein assays, interferes with some analytical methods, and introduces its own lot-to-lot variability

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Koller KJ, Coyle JT

In the DNBL (DNase 1-binding loop) mutant (3967), the ACTL6-specific region at the position equivalent to that of the DNase 1-binding domain of -actin was deleted