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In practice, GI side effects especially constipation are among the most common reasons patients struggle to stay on these medications

[PMID: 8795804] PubMed record related to this compound for laboratory literature review

Menstrual irregularities are not currently listed among the primary side effects in prescribing information for semaglutide or tirzepatide

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Pricing, medications, results, and which GLP-1 provider wins in 2026

[75] An observational study on patients with obesity and type 2 diabetes and heart failure with preserved ejection fraction reported that tirzepatide had a lower risk of hospitalization for heart failure and all-cause death combined than sitagliptin