The National Cancer Institute conducted chemoinformatics analysis of 60 cell lines and showed a negative correlation between xCT expression levels and sensitivity to compounds associated with GSH-mediated resistance, which indicated that xCT expression induces chemoresistance via GSH-mediated ROS detoxification activity (82)
This means only a tiny fraction of the antioxidant reaches your cells
Carnitine supplements can cause nausea, vomiting, abdominal cramps, diarrhea, a fishy body odor, as well as a few other health risks, including an increased risk of CVD (especially in vegans or vegetarians)
Finally, pharmacological targeting of the activity of -glutamyltransferases prevents the breakdown of circulating GSH, reduces tumour cysteine levels and slows tumour growth
Cell Metab (2006) 3(3):15365
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