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Furthermore, the duration of pain relief achieved using high-dose celecoxib appeared to be longer than that achieved with indomethacin (212)

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Dementia, stroke, and survival A 2025 JAMA Network Open analysis of nearly 61,000 adults with type 2 diabetes and obesity found GLP-1 users had a ~37% lower risk of dementia, ~19% lower risk of stroke, and ~30% lower all-cause mortality than people on other diabetes drugs

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Maintaining dietary changes and physical activity established during treatment can help minimise weight regain

Some reduction in training capacity may occur during the initial adjustment weeks, but most users return to baseline performance by week 10-12 as the body adapts to the new metabolic environment