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Both medications may cause serious side effects, including chest pain, swelling of the legs or ankles, irregular heartbeat, and mental or mood changes

H.DuschaA.et al (2018)

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Case presentation SL was a 44 year old Caucasian male with a past medical history of severe morbid obesity (BMI 99), heart failure with preserved ejection fraction, oxygen-dependent obesity hypoventilation syndrome (OHS), chronic non-healing leg wounds, anemia, uncontrolled hypertension on 2 anti-hypertensive agents, limited mobility, and major depressive disorder who presented to an academic medical center for treatment of acute on chronic diastolic heart failure due to progressive dyspnea

Active-loss markers include appetite, weight trend, waist, glucose, blood pressure, and tolerability