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At 5 mg weekly, about 5% of trial participants reported fatigue

5.8 Diabetic Retinopathy Complications in Patients with Type 2 Diabetes In a 2-year trial with semaglutide 0.5 mg and 1 mg once-weekly injection in adult patients with type 2 diabetes and high CV risk, diabetic retinopathy complications (which was a 4-component adjudicated endpoint) occurred in patients treated with semaglutide injection (3%) compared to placebo (1.8%)

In 2025, the FDA issued warnings to 15 brands making deceptive claims about containing real medication

Past that, discard

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However, in some individual cases, your doctor might suggest a pragmatic approach of reducing from a higher maintenance dose before complete discontinuation