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The same result was obtained in the active controlled studies (WMD = 2.37 kg, 95% CI 0.30 to 4.44, P = 0.02, I 2 = 0%), while there is no statistically significant distinction observed between the two subgroups ( P = 0.55) (Additional file 2: Fig

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Polyglutamylation of folate in cells ensures its metabolic retention and facilitates enzyme specificity [49], thereby supporting mitochondrial function and oxidative stress toleranceboth crucial for the persistence and activation of fibrogenic cells [7]

Liver Detoxification The liver utilizes glutathione to conjugate and eliminate toxins

Acknowledgement The authors would like to thank the UK Biobank for approving our application (#42468)