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Nishitani et al., 2025

Methodology: The PubMed and Embase databases were searched to screen studies associated with the pharmacokinetics of semaglutide

Sequential studies with a washout period are also a valid method to explore their effects without the risks of co-administration

Searches of the FAERS database and similar systems have shown some reports of people experiencing back pain while taking semaglutide

Start with smaller portions (46 ounces of protein per meal) if you are in your first 24 weeks on semaglutide, as your stomach adjusts

We tend to follow these guidelines, as the medications are very expensive if not covered. As effective as they are, she says, GLP-1s are not a quick fix, and theyre not for people who need or want to lose the 10-15 pounds that can accompany the transition into midlife (for those folks, Gennevs menopause-trained MDs and RDNs have many weight management strategies that can be tailored to patient goals)