Importantly, there was no exacerbation of psychiatric symptoms in these trials
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Some participants experienced only mild symptoms such as temporary nausea, while others experienced severe gastrointestinal issues, including nausea, vomiting, diarrhea, and stomach cramps
While this is a key research area, we propose that further investigations should verify whether GLP-1RAs may also affect cognitive and behavioral symptoms seen in psychosis, as suggested by their potential to influence neurobiological (for example, immune function) and neuropsychological (for example, reward) mechanisms that are known to be disrupted in psychotic illness
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