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At the same time, the free thiol group is also the source of GSHs characteristic sulfur odor, which poses significant challenges for product formulation

For example, copper ions can lead to GSH depletion through two mechanisms: the direct downregulation via the redox reaction between Cu 2+ and intracellular GSH, and the activation of a Fenton-like reaction by generating Cu + to amplify oxidative stress (Dong et al., 2020)

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Mild nausea or gut flushing: Rare, most often in patients starting at a higher dose than recommended