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Front Physiol 2019;10:914

Back in 2005, researchers conducted a randomized, double-blind, placebo-controlled study in 46 patients with ulcerative colitis

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Weight loss does slow after 6-12 months, but this is because you weigh less and need fewer calories, not because the medication stops working

Nmol/kg Range (Historical): Some early studies used 25 nmol/kg body weight, translating to approximately 2 mg for an 80 kg subject much higher dose than currently reported in wellness protocols