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Cells carry more receptors than the machinery downstream can use, so the effect can run near its ceiling while occupancy is still low (the spare-receptor effect). For retatrutide this gap is largest at the GLP-1 receptor, where the concentration that half-fills the appetite signal is roughly nine times lower than the concentration that half-fills the receptor itself

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doi:10.3390/ijns5030029 [17] Ramaswamy M, Anthony Skrinska V, Fayez Mitri R, Abdoh G

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