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Additional trials are also underway in participants with type 1 diabetes targeting diverse pathways including oxidative stress, using nicotinamide adenine dinucleotide phosphate oxidase (Nox)-1/4 inhibitors, and the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, using bardoxolone (NCT03366337, NCT03550443) [84, 85]

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This cohort was also used in Experiments 3 and 4

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Antioxidant properties of zinc Zinc deficiency is difficult to evaluate due to the lack of sensitive and specific biomarkers [155]