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In addition, there is evidence from preclinical studies that ES (POS in particular) affects mitochondria in the brain

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[9] The study hypothesized that Sermorelin may influence the pathway involving growth hormone and IGF-1, with IGF-1 levels correlated with growth hormone and thought to mediate hGH's anabolic actions

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Therefore, a more gradual dose escalation will likely decrease the severity and frequency of those specific side effects [49]