Copper ions in GHK-Cu can inhibit up to 90% of type 1 5-alpha reductase, potentially reducing DHT-related follicle miniaturization without systemic hormonal effects
Advanced Phase II conjugation reactions are catalyzed by superfamilies of transferase enzymes that use activated cosubstrates to form covalent bonds with electrophilic or nucleophilic centers on substrates
It is synthesised in the cytosol by glutamate-cysteine ligase (EC 6.3.2.2) and glutathione synthetase, with the first, rate-limiting step feedback-inhibited by glutathione itself and intracellular concentrations typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999)
de Lamirande E, Gagnon C
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Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG et al