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When you are anxious, your body's stress response kicks in: The hypothalamic-pituitary-adrenal axis releases cortisol Your amygdala becomes more reactive, and Communication with your prefrontal cortex, the part of your brain responsible for calm reasoning, weakens

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Topical bioavailability through intact stratum corneum is poor for this hydrophilic tripeptide without a penetration enhancer, a fact most product pages omit entirely