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Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma
ManellHStaafJManukyanLKristinssonHCenJStenlidRet al
However, in mouse models, administration of Parabacteroides distasonis accelerated progression of diabetes, primarily due to aberrant immune cross-reactivity and reduced Foxp3 + CD4 + Treg cells
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Any diagnostic or therapeutic inference drawn from the group-level GSH reduction therefore remains hypothesis-generating, and would need to be confirmed in larger, independent cohorts using longitudinal designs and ideally more objective indices of disease activity, such as prospective headache diaries or attack-phase measurements
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