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doi:10.1038/s41598-017-01305-2

doi:10.1128/AAC.01446-21 68

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DAMPs also impact Kupffer cells, activating the nucleotide-binding oligomerization domain-like receptor (NLR) Family, Pyrin Domain-Containing 3 protein (NLRP3), a type of inflammasome leading to IL-1 secretion and inflammation, and pyroptosis, releasing more DAMPs and perpetuating a destructive cycle (Hammerich and Tacke, 2023)