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Larger and longer studies in broader populations are needed to fully understand the safety and efficacy in people with alcohol use disorder, but these initial findings are promising. About this study: In addition to Hendershot and Klein, other authors of the study are Michael Bremmer, Michael Paladino, Georgios Kostantinis, Thomas Gilmore, Neil Sullivan, Amanda Tow and Robyn Jordan, all of University of North Carolina at Chapel Hill

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Key genes include GLP1R (the GLP-1 receptor), GIPR (the GIP receptor targeted by dual agonists), TCF7L2 (strongly linked to type 2 diabetes and incretin-driven insulin secretion), and FTO (appetite and body weight)

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After discontinuing semaglutide but continuing metformin for two years, they regained only one-third of their lost weight , with 21 out of 25 women maintaining a lower weight than their starting baseline

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