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Changes in the appearance of the face or feet are not listed as separate side effects in patient information leaflets
Other reported side effects include vomiting, allergic reactions, and a fluctuating libido
Most discontinuations were GI-related
CVOs are highly permeable with fenestrated capillaries, allowing polypeptides to exit the brain and enabling substances like metabolic hormones and drugs, which typically do not cross the bloodbrain barrier, to influence brain function 52,53
Weight matters more with age, since excess weight can limit mobility and add to other health risks
Proceedings of the National Academy of Sciences of the United States of America , 101 (27), 1020110204
