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GLP-1 medications are approved for adults who have a body mass index (BMI) of 30 or higher, or a BMI of at least 27 plus a weight-related medical condition, such as the following: Type 2 diabetes High blood pressure High cholesterol Obstructive sleep apnea Cardiovascular disease that increases the risk of heart attack or stroke MASH, or metabolic dysfunctionassociated steatohepatitis, a form of liver inflammation Avlin Imaeda, MD, PhD, a Yale Medicine gastroenterologist who is board-certified in obesity medicine, notes that qualifying for the medication based on heart disease aloneoften necessary for insurance coveragecan be challenging
Slower titration is a legitimate option for GI-sensitive patients, with evidence that it improves long-term persistence
Choosing filling foods: Use foods that are high in fiber, lean sources of protein, and healthy fats
2024. Farr OM et al
The combination can be powerful but introduces more complexity and potential for unexpected interactions
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