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Research also suggests that a deficiency in lipotropes can lead to liver fat accumulation and other metabolic disturbances, highlighting their potential role in supporting liver function and metabolic balance

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Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) complex 1, exhibits cardioprotective effects in ferroptotic cells, where mTOR overexpression protects against iron-overload-induced cell death, a process exacerbated by mTOR deficiency (67, 68)

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Certain organ diseases and especially tumors are associated with the occurrence of this pathological manifestation

As a key mediator of ferroptosis, GPX4 is mainly expressed by TECs and is downregulated in DKD patients (131)