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Yuan B, Ly S, Veletic I, Malsonado K, Zhou X, deCrombrugghe B, Andreeff M , Battula VL

Free radicals are unstable molecules that damage cells, proteins, and DNA

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[1] Selectivity testing indicated the scaffold did not inhibit related SAM-dependent methyltransferases or NAD+ salvage enzymes

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The dopamine metabolic pathway mediated by MAO-B can generate hydrogen peroxide (H 2 O 2 ), and with the increase of MAO-B activity, excessive H 2 O 2 leads to oxidative stress and neuronal damage (Jiang et al., 2015a)