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OA-VI12 was shown to promote the expression of miR-122-5p while downregulating the expression of MITF and TYR, suggesting that it inhibited melanin synthesis through the miR-122-5p/MITF/TYR axis

Notably, GLP-1 directly interacts with vagal afferent neurons 19 , and surgical or chemical denervation of vagal afferents and specific Glp1r knockdown in vagal afferent neurons attenuate anorexigenic, insulinotropic and glycemic effects of exogenous GLP-1 and dipeptidyl peptide-4 (DPP-4

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10.1002/advs.202001549 12 DongY.DongS.LiuB.YuC.LiuJ.YangD.et al (2021)

GLP-1 Case Study Name: Richard J., a 58-year-old male Medical History: Type 2 Diabetes Mellitus (diagnosed 7 years ago) Obesity (BMI 35 kg/m) Hypertension (well-controlled on an ACE inhibitor) Mild diabetic retinopathy Current Medications: Metformin 1000 mg twice daily, glimepiride 2 mg once daily, and lisinopril 20 mg once daily Clinical Presentation Richard presents a routine follow-up

The anti-inflammatory effects of AC have been strongly related to its antioxidant role, where in an osteoarthritis rat model, the reduction in NF-B was accompanied by diminished reactive oxygen species (ROS) production (Ma et al