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Key Takeaway: If you don't see results, the problem is often absorption
A 2013 meta-analysis of 17 randomized, placebo-controlled studies in a total of 1,625 participants with heart failure found that oral L-carnitine (1.5-6 g/day for seven days to three years) significantly improved several measures of cardiac functional capacity (including exercise tolerance and markers of the left ventricle function), yet had no impact on all-cause mortality (56)
( in vivo and in vitro
Stimuliresponsive silica silanol conjugates: strategic nanoarchitectonics in targeted drug delivery
This sounds excessive, but the impact on absorption is real
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