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514 UPR signaling in neuroinflammation, oligodendrocyte survival, and demyelination in MS ER stress is widely observed in demyelinating lesions in MS, with elevated levels of markers such as CHOP, BiP, phosphorylated PERK, phosphorylated eIF2, and XBP-1 in microglia, oligodendrocytes (OLs), T cells, and astrocytes

Ganglionic expression of GLP-1Rs, which are most evident in neuronal cell membranes and extra-neuronal cells, was unchanged by direct exposure of submucosal neurons to indole (optical density: 11.3 1.0 vs

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These advanced formulations could potentially overcome the pharmacokinetic limitations that have historically constrained SFNs clinical efficacy