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Both studies had the same lead author, Julia J
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Abbreviations DPP-4: Dipeptidyl peptidase-4 EMA: European Medicines Agency EPAC: Exchange protein directly activated by cAMP FDA: Food and Drug Administration FGF21: Fibroblast growth factor 21 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 PKA: Protein kinase A SGLT-2: Sodiumglucose cotransporter 2 References Moore B, Edie ES, Abram JS (1906) On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane
L-arginine is utilized in the synthesis of nitric oxide by NOS3
The authors write that they suspect the two medications had synergistic effects in the patient, leading to adequate control of his blood sugars yet a state of starvation, ketone production, and resultant systemic acidification
The plan is to offer patients a "long-term extension period" for their trials, giving whoever receives the placebo a chance to then switch and take the experimental drug
