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Results Local disruption of Gs signaling in the dorsal vagal complex impairs energy balance and semaglutide-induced weight loss To test whether semaglutide recruits the Gs pathway in hindbrain neurons to drive weight loss, we delivered a virus encoding Cre recombinase and a red fluorescent protein (AAV1-hsyn-cre-P2A-tdTomato) to the dorsal vagal complex (DVC) of Gnas conditional knockout mice 29 (Gnas fl/fl ) to selectively knockout the gene encoding the Gs protein (Fig

Eye (Lond) 33(3):478485 Daniels AB et al (2007) Profiles of obesity, weight gain, and quality of life in idiopathic intracranial hypertension (pseudotumor cerebri)

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