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The AWARD-7 trial, which is notable for its exclusive focus on patients with moderate-to-severe chronic kidney disease, demonstrated that dulaglutide users, particularly those simultaneously using ACE inhibitors or angiotensin receptor blockers, exhibited a substantially less eGFR decline compared to insulin glargine users
The combination is mechanistically rational because they act on different receptors (GHRH-R and GHSR-1a)
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GLP-1 receptor agonist fatigue mechanism is an important consideration for clinicians managing patients on medications like semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)