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The STEP trial data shows that the cumulative incidence of gastrointestinal adverse events peaks around week 20 and plateaus thereafter

For highly complex biologics with long batch cycle times, this creates meaningful supply risk in the first weeks after LOE

When the protective lining of your stomach becomes inflamed, irritated, or eroded, we call it gastritis

furthermore, the S2-only vaccine was shown to induce nAb to both - and - coronaviruses (presumably to the fusion peptide as has been described in humans [69]), and it boosted a more broadly targeting antibody response overall than repeated homologous full-length spike vaccines [73]

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