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Ten patients received semaglutide 1.0 mg, and one patient each received semaglutide 0.5 mg, liraglutide 1.2 mg and liraglutide 2.4 mg (maximum tolerated dose)

LDH activity was assayed using a standard spectrophotometric technique described by Koh and Choi (1987)

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To dissect the upstream regulatory mechanism of miR-29b-3p under Gln deprivation conditions, we integrated transcriptome data (GSE148016) from both Gln+ and Gln- groups, and performed cross-analysis with the predicted upstream transcription factors of miR-29b-3p, ultimately identifying five candidate transcription factors